Why Cannabis Oil Suppositories are a Better choice for Cancer Treatments
During rectal administration, fluids are absorbed by the rectum's blood vessels and are mostly directed into the body's circulatory system, which distributes the fluid to the organs and bodily systems. Typically, a drug that is administered rectally has a faster onset, a higher bioavailability, a shorter peak, and a shorter duration than when the same drug is administered orally.
This route of administration partially bypasses first-pass metabolism. The rectum's venous drainage is two-thirds systemic (consisting of the middle and the inferior rectal vein) and one-third hepatic (the superior rectal vein). Drugs administered rectally typically reach the blood stream with significantly less hepatic alteration.
Multiple factors affect the absorption rate of rectal medications, including molecular size, water-solubility, depth of insertion, dehydration, low surface area, and the base of a suppository preparation. Additionally, absorption rates of suppositories are slower than that of other delivery methods and the rate at which suppositories absorb is largely dependent on chemical additives in the suppository.
CBD International CO210-Series rectal administration is advantageous because patients can take larger doses while avoiding psychoactivity. However, cannabinoids absorbed through the rectum should flow into the blood stream through one of two possible routes:
By either routes, there should be detectable levels of THC in the plasma and those levels should correspond to a discernible psychoactivity. The reason no psychoactivity is reported is that the cannabinoids have not been adequately absorbed into the bloodstream. Patients who use high THC products through rectal administration and who fail to feel any psychoactive side effects are likely not improving any systemic issues. Of course, patients have reported that they have successfully treated conditions and disease with cannabis suppositories, but there may be other factors to consider. For example, patients may be combining cannabis with other treatment modalities. It’s likely that the quality of the medicine, the cannabinoid profile, and the terpene profile are all contributing factors. And, perhaps very low doses of cannabis can, in fact, contribute significantly to efficacy and treatment success. |