Why Cannabis Oil Suppositories are a Better choice for Cancer Treatments

Rectal treatment insertion options are a popular method of Cannabis Oil administration and can be very effective at treating certain conditions and diseases. However, information available on healthcare forums, blogs, and social media posts include prevalent misconceptions about the efficacy of suppositories and erroneous interpretations of the existing research. We hope the following information should enable you to make more informed decision about which delivery method is best to treat your or you're loved ones condition.
During rectal administration, fluids are absorbed by the rectum's blood vessels and are mostly directed into the body's circulatory system, which distributes the fluid to the organs and bodily systems. Typically, a drug that is administered rectally has a faster onset, a higher bioavailability, a shorter peak, and a shorter duration than when the same drug is administered orally.
This route of administration partially bypasses first-pass metabolism. The rectum's venous drainage is two-thirds systemic (consisting of the middle and the inferior rectal vein) and one-third hepatic (the superior rectal vein). Drugs administered rectally typically reach the blood stream with significantly less hepatic alteration.

Multiple factors affect the absorption rate of rectal medications, including molecular size, water-solubility, depth of insertion, dehydration, low surface area, and the base of a suppository preparation. Additionally, absorption rates of suppositories are slower than that of other delivery methods and the rate at which suppositories absorb is largely dependent on chemical additives in the suppository.
Currently, there is some debate about whether rectally administered cannabis can effectively treat conditions that affect the entire body. Commonly-referenced research states that rectal absorption rates of cannabis are as High as 50-70%. However to achieve that bio-availability, Delta-9-THC has to be coupled with the ester Hemisuccinate, which is an addition step required to increase absorbency by breaking down fat-soluble compounds into water-soluble compounds. As with CO210R-Series which is THC-HS formulated.

Unfortunately, Rectal absorption of cannabis oil indicates that without the addition combination of Hemisuccinate, The rectal absorbency is 3% or less. and most likely in-effective in treatment, there exists some general agreement that fats and oils are poorly absorbed from the rectum. Cannabinoids are lipids (fats) and cannabis products are nearly always extracted into an oil or fat base, so it reasonable to assume that whole plant cannabis oil products are poorly absorbed rectally. And, because the majority of preparations of cannabis suppositories do not contain hemisuccinate, it is safe to assume that most of these preparations are not being adequately absorbed. 
CBD International CO210-Series rectal administration is advantageous because patients can take larger doses while avoiding psychoactivity. However, cannabinoids absorbed through the rectum should flow into the blood stream through one of two possible routes:
  • Pass into the middle and the inferior rectal veins and eventually flow into the blood stream.
  • Pass into the superior rectal vein and through the liver circulation (where they are metabolized by enzymatic processes) and eventually flow into the blood stream.
​

By either routes, there should be detectable levels of THC in the plasma and those levels should correspond to a discernible psychoactivity. The reason no psychoactivity is reported is that the cannabinoids have not been adequately absorbed into the bloodstream. Patients who use high THC products through rectal administration and who fail to feel any psychoactive side effects are likely not improving any systemic issues.

Of course, patients have reported that they have successfully treated conditions and disease with cannabis suppositories, but there may be other factors to consider. For example, patients may be combining cannabis with other treatment modalities. It’s likely that the quality of the medicine, the cannabinoid profile, and the terpene profile are all contributing factors. And, perhaps very low doses of cannabis can, in fact, contribute significantly to efficacy and treatment success.
CBD International prioritizes patient care, along with traditional western medicine. With nearly 16 years of experience, we’re a world online  leader in alternative cancer treatments. See how we can help you.
* Disclaimer: The content presented on this website is intended for general informational purposes only and should not be considered cancer treatment advice. The results of cancer treatments featured on this website may not be typical, and no guarantee is offered regarding the efficacy of any treatment or therapy. It is important to note that every patient’s cancer journey is unique, and individual results may vary depending on factors such as cancer type, stage, medical history, and response to treatment. Therefore, you should not expect to achieve the same results as other cancer patients featured on this website. Always consult with our qualified cancer doctor experts for personalized medical advice and treatment recommendations.
​Our products are not for use or sale to persons under the age of 19. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing.​ These products have not been evaluated by the Food and Drug Administration or Health Canada. These products are not intended to diagnose, treat, cure, or prevent any diseases. results may vary.